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Guntersville is located at the southernmost point of the Tennessee River, situated 150 miles west of Atlanta, 150 miles south of Nashville, 70 miles northeast of Birmingham, and 30 miles south of Huntsville.
Highway 431 is the major artery through Guntersville. State highways 79, 69, and 205 also pass through Guntersville. Interstate 59 is 26 miles south and Interstate 65 is 40 miles west.
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